| First Author | Wielowieyski A | Year | 1999 |
| Journal | Mamm Genome | Volume | 10 |
| Issue | 6 | Pages | 623-7 |
| PubMed ID | 10341098 | Mgi Jnum | J:55012 |
| Mgi Id | MGI:1336977 | Doi | 10.1007/s003359901057 |
| Citation | Wielowieyski A, et al. (1999) Tli1, a resistance locus for carcinogen-induced T-lymphoma. Mamm Genome 10(6):623-7 |
| abstractText | Within 180 days after injection with N-methyl-N- nitrosourea (MNU), 83.5% of AKR/J mice and 37.5% of BALB/ cJ mice developed T-lymphoma. The high tumor incidence was a dominant trait, as 93% of MNU-injected F-1 mice developed T-lymphoma. A genome screen of 285 MNU-injected F-2 mice identified a locus, designated T-lymphoma Induced 1 or Tli1, in a similar to 10-cM interval on central Chr 1 between D1Mit87 and D1Mit423 with significant linkage to the incidence of MNU-induced T-lymphoma (P = 0.0004). Injection of BALB/cJ.AKR/J-Tli1 congenic mice with MNU confirmed the presence of Tli1 on central Chr 1. Mice homozygous for the BALB/cJ allele (Tli1(bb)) were over- represented in the tumor-free F-2 mice, while the inheritance of parental alleles of Tli1 in turner-bearing mice was close to expected. This suggests that the Tli1(b) allele is recessive and suppresses MNU-induced T-lymphoma development in BALB/cJ mice and in Tli1(bb) F-2 mice. Furthermore, the kinetics of lymphoma development in BALB/ cJ and the Tli1 congenic mice suggests that Tli1(b) acts to suppress lymphomas developing late after injection with MNU. Two known genes that map in the identified genomic interval on central Chr 1 are candidates for Tli1:IL10, encoding the lymphokine IL10, and Cmkar4, encoding the chemokine receptor CXCR4. |
