| First Author | Fernandes MJ | Year | 1999 |
| Journal | Cancer Res | Volume | 59 |
| Issue | 11 | Pages | 2709-17 |
| PubMed ID | 10363996 | Mgi Jnum | J:55818 |
| Mgi Id | MGI:1339437 | Citation | Fernandes MJ, et al. (1999) Characterization of a novel receptor that maps near the natural killer gene complex: demonstration of carbohydrate binding and expression in hematopoietic cells. Cancer Res 59(11):2709-17 |
| abstractText | A novel type II integral membrane protein has been identified in the course of screening for genes overexpressed in a mouse model of chronic myelogenous leukemia blast crisis. This new protein, designated NKCL, consists of a 210-amino acid polypeptide with a short, NH2- terminal cytoplasmic tail of 17 amino acids preceding a transmembrane domain and a COOH-terminal extracellular region. The COOH-terminal 132 amino acids bear typical features of the C-type animal lectin carbohydrate- recognition domain. The Nkcl gene is unique in that it maps just proximal to the region of the genome that encodes group V members of the C-type animal lectin family near the natural killer gene complex on mouse chromosome 6, but its protein product also has features of several group II C-type animal lectins, Most notably, it has a complete Ca2+-binding site 2, which forms part of the sugar-binding site in other members of the family, and binds mannose in a Ca2+-dependent manner. Moreover, its expression is not restricted to natural killer cells, as reported for the majority of group V lectins, Nkcl is expressed in pluripotent myeloid precursors, precursor and mature macrophages, and neutrophils. |
