| First Author | Saito T | Year | 1999 |
| Journal | Biochem Biophys Res Commun | Volume | 260 |
| Issue | 2 | Pages | 329-31 |
| PubMed ID | 10403770 | Mgi Jnum | J:56570 |
| Mgi Id | MGI:1341937 | Doi | 10.1006/bbrc.1999.0911 |
| Citation | Saito T, et al. (1999) ICSAT overexpression is not sufficient to cause adult T-cell leukemia or multiple myeloma. Biochem Biophys Res Commun 260(2):329-31 |
| abstractText | ICSAT (Interferon Consensus Sequence binding protein for Activated T cells) is a lymphocyte-specific member of the interferon regulatory factor (IRF) family of transcription factors, originally identified through Southwestern screening of the ATL(Adult T-cell leukemia)-16T expression library. In this study, we created transgenic mice overexpressing ICSAT in lymphocytes. Although spontaneous tumorigenesis was not observed, IL-2 production with Concanavalin A stimulation was significantly increased in transgenic mice overexpressing ICSAT. ICSAT overexpression in lymphocytes seems insufficient for the leukemogenesis of ATL or multiple myeloma (MM), however, it may regulate T cell activation and its overexpression may lead to leukemogenesis via controlling IL-2 production. Copyright 1999 Academic Press. |
