| First Author | Zhang M | Year | 1999 |
| Journal | Genomics | Volume | 59 |
| Issue | 2 | Pages | 252-4 |
| PubMed ID | 10409438 | Mgi Jnum | J:56711 |
| Mgi Id | MGI:1342205 | Doi | 10.1006/geno.1999.5866 |
| Citation | Zhang M, et al. (1999) Cloning and mapping of the XRN2 gene to human chromosome 20p11.1-p11.2. Genomics 59(2):252-4 |
| abstractText | The Dhm1 gene is the mouse homologue of the dhp1(+) gene of Schizosaccharomyces pombe, which is involved in homologous recombination and RNA metabolism, such as RNA synthesis and RNA trafficking, in S. pombe. Complementation analysis showed the Dhm1 gene on a multicopy plasmid can rescue the temperature-sensitivity mutation of dhp1(ts) and the lethality of the dhp1 null mutation. This finding suggests that Dhm1 has a function in mouse similar to that of dhp1(+). The human homologue of this gene, XRN2, has been identified. A 3.6-kb transcript of XRN2 was detected in 16 tissues examined and was more abundant in testis. By radiation hybrid panel mapping, the XRN2 gene was localized to chromosome 20p11.1-p11.2 between markers D20S180 and D20S871. Copyright 1999 Academic Press. |
