| First Author | Arai M | Year | 1999 |
| Journal | Dev Dyn | Volume | 215 |
| Issue | 4 | Pages | 297-307 |
| PubMed ID | 10417819 | Mgi Jnum | J:56669 |
| Mgi Id | MGI:1342163 | Doi | 10.1002/(SICI)1097-0177(199908)215:4<297::AID-AJA2>3.0.CO;2-I |
| Citation | Arai M, et al. (1999) Differential developmentally regulated expression of gelsolin family members in the mouse. Dev Dyn 215(4):297-307 |
| abstractText | The gelsolin family of actin-modulating proteins contains seven mammalian members of which three have similar domain structure and function: gelsolin, capG, and adseverin. Previous studies have provided some information on the expression of these proteins, but no comprehensive analysis of expression during development has been performed. By in situ hybridization to murine embryo sections, we show that gelsolin expression is widespread but focal from e12.5 onward, with the exception of brain and mucosal epithelium. In contrast, CapG expression is high in mucosal epithelium, inner renal medulla, and adrenal cortex, and seen at much lower levels more broadly. Adseverin expression is even more restricted, being seen at sites of endochondral bone formation during development only, and in developing and adult outer renal medulla and intestine. In parallel analyses the three genes demonstrated patterns of expression that were complementary and non-overlapping in nearly all organs. The observations suggest new functions for these proteins in organ systems and tissues where their expression was not previously recognized. They further suggest that the proteins have distinct tissue-specific functions in modulating the actin cytoskeleton during cellular motile activities, and that such functions have diverged since the genes arose ancestrally by gene duplication. Dev Dyn 1999;215:297-307. Copyright 1999 Wiley-Liss, Inc. |
