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Publication : A tale of three fingers: the family of mammalian Sp/XKLF transcription factors.

First Author  Philipsen S Year  1999
Journal  Nucleic Acids Res Volume  27
Issue  15 Pages  2991-3000
PubMed ID  10454592 Mgi Jnum  J:56736
Mgi Id  MGI:1342365 Doi  10.1093/nar/27.15.2991
Citation  Philipsen S, et al. (1999) A tale of three fingers: the family of mammalian Sp/XKLF transcription factors. Nucleic Acids Res 27(15):2991-3000
abstractText  One of the most common regulatory elements is the GC box and the related GT/CACC box, which are widely distributed in promoters, enhancers and locus control regions of housekeeping as well as tissue-specific genes. For long it was generally thought that Sp1 is the major factor acting through these motifs. Recent discoveries have shown that Sp1 is only one of many transcription factors binding and acting through these elements. Sp1 simply represents the first identified and cloned protein of a family of transcription factors characterised by a highly conserved DNA-binding domain consisting of three zinc fingers. Currently this new family of transcription factors has at least 16 different mammalian members. Here, we will summarise and discuss recent advances that have been directed towards understanding the biological role of these proteins.
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