| First Author | Qiu BS | Year | 1999 |
| Journal | Nat Med | Volume | 5 |
| Issue | 10 | Pages | 1178-82 |
| PubMed ID | 10502822 | Mgi Jnum | J:57935 |
| Mgi Id | MGI:1346221 | Doi | 10.1038/13503 |
| Citation | Qiu BS, et al. (1999) The role of CD4+ lymphocytes in the susceptibility of mice to stress-induced reactivation of experimental colitis. Nat Med 5(10):1178-82 |
| abstractText | Idiopathic inflammatory bowel disease is a chronic relapsing condition. The role of stress in causing relapses of inflammatory bowel disease remains controversial. We now show that colitis induced in mice by dinitrobenzenesulfonic acid (DNBS) resolves by 6 weeks, but can subsequently be reactivated by stress plus a sub-threshold dose of DNBS, but not by DNBS alone. Stress reduced colonic mucin and increased colon permeability. Susceptibility to reactivation by stress required CD4+ lymphocytes and could be adoptively transferred. We conclude that stress reactivates experimental colitis by facilitating entry of luminal contents that activate previously sensitized CD4 cells in the colon. |
