| First Author | Dong Z | Year | 1999 |
| Journal | Gene | Volume | 237 |
| Issue | 2 | Pages | 421-8 |
| PubMed ID | 10521666 | Mgi Jnum | J:57768 |
| Mgi Id | MGI:1345783 | Doi | 10.1016/s0378-1119(99)00303-0 |
| Citation | Dong Z, et al. (1999) SIN, a novel Drosophila protein that associates with the RNA binding protein sex-lethal. Gene 237(2):421-8 |
| abstractText | Sex-lethal (SXL) is an RNA binding protein that acts as a regulator of both alternative pre-mRNA splicing and translation. Because SXL must sometimes function at some distance from its binding sites, it is believed that it must interact with other proteins. We used a yeast two-hybrid screen to isolate a novel Drosophila protein, SIN (SXL interactor), that interacts specifically with SXL. A direct physical association was demonstrated in vitro, and a single SXL RNA binding domain was sufficient for the interaction. SIN shows a high degree of similarity to a mammalian protein of unknown function. The cytogenetic location of Sin is 78A2-4. The transcript, which is abundant in early embryos, appears to be of maternal origin. |
