| First Author | Strettoi E | Year | 2002 |
| Journal | J Comp Neurol | Volume | 446 |
| Issue | 1 | Pages | 1-10 |
| PubMed ID | 11920715 | Mgi Jnum | J:75484 |
| Mgi Id | MGI:2176677 | Doi | 10.1002/cne.10177 |
| Citation | Strettoi E, et al. (2002) Retinal organization in the bcl-2-overexpressing transgenic mouse. J Comp Neurol 446(1):1-10 |
| abstractText | Naturally occurring cell death is believed to play a major role during the development of the nervous system in the establishment of neuronal architecture. Here we study the effects of cell death inhibition by using a transgenic mouse in which the powerful antiapototic gene bcl-2 is expressed in neurons. The retina of this mouse reveals that the general neuronal plan has been maintained. However, bcl-2 overexpression leads to altered frequencies of the major cell types in the retina. Thus, it is possible to estimate cell-type-specific rates of apoptosis by observing the increases in numbers of cells in the bcl-2-overexpressing transgenic mouse. |
