| First Author | Liang H | Year | 2000 |
| Journal | Genomics | Volume | 66 |
| Issue | 2 | Pages | 226-8 |
| PubMed ID | 10860669 | Mgi Jnum | J:76447 |
| Mgi Id | MGI:2179516 | Doi | 10.1006/geno.2000.6198 |
| Citation | Liang H, et al. (2000) Chromosomal mapping and genomic organization of an evolutionarily conserved zinc finger gene ZNF277. Genomics 66(2):226-8 |
| abstractText | A novel C2H2 zinc finger gene, ZNF277, has been localized to human chromosome 7q31.1. The gene is encoded by 12 exons in a genomic fragment of >100 kb between the microsatellite markers D7S523 and D7S471, deleted in a number of malignancies. The predicted open reading frame (ORF) of 438 amino acids shows an overall homology of 50% to the putative ORF F46B6.7 of Caenorhabditis elegans. The presence of a 30-amino-acid coiled-coil domain in both the C. elegans ORF F46B6.7 and ZNF277 is suggestive of functional similarities. ESTs for the murine orthologue ZFP277 are found in early embryonic stem cells, 16-cell stage embryo, and blastocysts. The evolutionary conservation and the expression profile suggest ZNF277 to be a critical regulator of development and differentiation. |
