| First Author | Essner JJ | Year | 2002 |
| Journal | Nature | Volume | 418 |
| Issue | 6893 | Pages | 37-8 |
| PubMed ID | 12097899 | Mgi Jnum | J:77529 |
| Mgi Id | MGI:2181930 | Doi | 10.1038/418037a |
| Citation | Essner JJ, et al. (2002) Conserved function for embryonic nodal cilia. Nature 418(6893):37-8 |
| abstractText | How left right handedness originates in the body plan of the developing vertebrate embryo is a subject of considerable debate. In mice, a left right bias is thought to arise from a directional extracellular flow (nodal flow) that is generated by dynein-dependent rotation of monocilia on the ventral surface of the embryonic node. Here we show that the existence of node monocilia and the expression of a dynein gene that is implicated in ciliary function are conserved across a wide range of vertebrate classes, indicating that a similar ciliary mechanism may underlie the establishment of handedness in all vertebrates. |
