| First Author | Izikson L | Year | 2002 |
| Journal | Clin Immunol | Volume | 103 |
| Issue | 2 | Pages | 125-31 |
| PubMed ID | 12027417 | Mgi Jnum | J:76939 |
| Mgi Id | MGI:2180622 | Doi | 10.1006/clim.2001.5167 |
| Citation | Izikson L, et al. (2002) Targeting monocyte recruitment in CNS autoimmune disease. Clin Immunol 103(2):125-31 |
| abstractText | Monocytes and macrophages play a pathogenic role in a number of autoimmune inflammatory diseases. Recent studies in experimental autoimmune encephalomyelitis (EAE), the animal model of multiple sclerosis, have identified a critical chemokine-mediated mechanism of monocyte homing to the central nervous system (CNS). Here, we summarize the current findings in EAE, develop a rationale for targeting the chemokine axis in order to treat CNS inflammatory disease, and review currently available molecule-specific therapeutics that inhibit monocyte trafficking to the CNS. |
