| First Author | Ohmori H | Year | 2002 |
| Journal | Immunol Lett | Volume | 83 |
| Issue | 2 | Pages | 95-9 |
| PubMed ID | 12067757 | Mgi Jnum | J:78269 |
| Mgi Id | MGI:2183878 | Doi | 10.1016/s0165-2478(02)00083-4 |
| Citation | Ohmori H, et al. (2002) Role for complement receptors (CD21/CD35) in the regulation of recombination activating gene expression in murine peripheral B cells. Immunol Lett 83(2):95-9 |
| abstractText | A population of peripheral B cells have been shown to express recombination activating gene products, RAG-1 and RAG-2, which are considered to be involved in revising the B cell antigen receptor (BCR) in the periphery. BCR engagement has been reported to turn off RAG expression in peripheral B cells, whereas the same treatment has an opposite effect on immature B cells in the bone marrow. In contrast to receptor editing that is involved in the removal of autoreactivity in immature B cells, it has been shown that secondary V(D)J rearrangement in peripheral B cells, termed receptor revision, contributes to affinity maturation of antibodies. Here, we show that RAG-2 expression in murine splenic B cells was abrogated by the coligation of BCR with complement receptors (CD21/CD35) much more efficiently than by the engagement of BCR alone. On the other hand, the same coligation augmented proliferation of anti-CD40-stimulated B cells. These findings suggest a crucial role for CD21/CD35 in directing the conservation or the revision of BCRs in peripheral B cells. |
