| First Author | Herold S | Year | 2002 |
| Journal | Mol Cell | Volume | 10 |
| Issue | 3 | Pages | 509-21 |
| PubMed ID | 12408820 | Mgi Jnum | J:79336 |
| Mgi Id | MGI:2387875 | Doi | 10.1016/s1097-2765(02)00633-0 |
| Citation | Herold S, et al. (2002) Negative Regulation of the Mammalian UV Response by Myc through Association with Miz-1. Mol Cell 10(3):509-21 |
| abstractText | The Myc oncoprotein represses initiator-dependent transcription through the POZ domain transcription factor Miz-1. We now show that transactivation by Miz-1 is negatively regulated by association with topoisomerase II binding protein (TopBP1); UV irradiation downregulates expression of TopBP1 and releases Miz-1. Miz-1 binds to the p21Cip1 core promoter in vivo and is required for upregulation of p21Cip1 upon UV irradiation. Using both c-myc(-/-) cells and a point mutant of Myc that is deficient in Miz-1 dependent repression, we show that Myc negatively regulates transcription of p21Cip1 upon UV irradiation and facilitates recovery from UV-induced cell cycle arrest through binding to Miz-1. Our data implicate Miz-1 in a pathway that regulates cell proliferation in response to UV irradiation. |
