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Publication : Developmental changes and localization of mouse brain serine proteinase mRNA and protein in mouse brain.

First Author  Yokoi T Year  2002
Journal  Neurosci Lett Volume  323
Issue  2 Pages  133-6
PubMed ID  11950511 Mgi Jnum  J:79934
Mgi Id  MGI:2389597 Doi  10.1016/s0304-3940(02)00122-2
Citation  Yokoi T, et al. (2002) Developmental changes and localization of mouse brain serine proteinase mRNA and protein in mouse brain. Neurosci Lett 323(2):133-6
abstractText  Serine proteases are known to be involved in neural development and various functions in the central nervous system. Mouse brain serine proteinase (mBSP) is expressed almost exclusively in the mouse brain and it has been characterized at the molecular and biochemical levels. In this study, we analyzed the developmental changes and localization of mBSP mRNA and protein in the mouse brain, using reverse transcription-polymerase chain reaction, Western blotting, and immunohistochemistry. Expression of mBSP was strong in the white matter and the nerve tracts after postnatal day 30, especially in the cerebellum and the medulla oblongata. These results suggest that mBSP contributes to development and sustaining the functions in the mouse brain.
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