| First Author | Chtarbova S | Year | 2002 |
| Journal | Biochem J | Volume | 367 |
| Issue | Pt 3 | Pages | 723-8 |
| PubMed ID | 12153396 | Mgi Jnum | J:79982 |
| Mgi Id | MGI:2429359 | Doi | 10.1042/BJ20020699 |
| Citation | Chtarbova S, et al. (2002) Murine Nr4a1 and Herpud1 are up-regulated by Wnt-1, but the homologous human genes are independent from beta-catenin activation. Biochem J 367(Pt 3):723-8 |
| abstractText | The Wnt signal transduction pathway regulates morphogenesis and mitogenesis of cells in multicellular organisms. A major downstream consequence of Wnt-1 signalling is the activation of beta-catenin/T-cell factor (TCF)-mediated transcription. We compared Wnt-1-transformed murine mammary epithelial cells with control cells by subtractive hybridization. We found the two genes Nr4a1 and Herpud1 to be overexpressed in Wnt-1-transformed cells. Remarkably, the transcription levels of the two homologous human genes NR4A1 and HERPUD1 are neither activated in cells with activated beta-catenin/TCF-mediated transcription nor can be induced by beta-catenin transfection. These results indicate different regulation mechanisms of the two genes in murine and human cells. |
