| First Author | Krebs J | Year | 2002 |
| Journal | Biochim Biophys Acta | Volume | 1600 |
| Issue | 1-2 | Pages | 68-73 |
| PubMed ID | 12445461 | Mgi Jnum | J:80591 |
| Mgi Id | MGI:2446386 | Doi | 10.1016/s1570-9639(02)00446-6 |
| Citation | Krebs J, et al. (2002) ALG-2: a Ca(2+)-binding modulator protein involved in cell proliferation and in cell death. Biochim Biophys Acta 1600(1-2):68-73 |
| abstractText | During the development of an organism, cell proliferation, differentiation and cell death are tightly balanced, and are controlled by a number of different regulators. Alterations in this balance are often observed in a variety of human diseases. The role of Ca(2+) as one of the key regulators of the cell is discussed with respect to a recently discovered Ca(2+)-binding protein, ALG-2, which is highly upregulated in cancerous tissues of different origins. The role of ALG-2 as a possible clinical marker and, molecularly, as a possible modulator at the interface between cell proliferation and cell death is discussed. |
