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Publication : Developmental regulation of neural response to FGF-1 and FGF-2 by heparan sulfate proteoglycan.

First Author  Nurcombe V Year  1993
Journal  Science Volume  260
Issue  5104 Pages  103-6
PubMed ID  7682010 Mgi Jnum  J:80964
Mgi Id  MGI:2447841 Doi  10.1126/science.7682010
Citation  Nurcombe V, et al. (1993) Developmental regulation of neural response to FGF-1 and FGF-2 by heparan sulfate proteoglycan. Science 260(5104):103-6
abstractText  Murine neural precursor cells and cell lines derived from them are stimulated by members of the heparin-binding fibroblast growth factor (FGF) family. The activity of FGF is regulated by heparan sulfate proteoglycans (HSPGs), and this interaction is an essential prerequisite for the binding of growth factor to the signal transducing receptors. Messenger RNA for FGF-2 was detectable in the neuroepithelium at embryonic day 9, and the HSPGs produced by these cells at this time preferentially bound FGF-2. However, at embryonic day 11, when messenger RNA for FGF-1 was first detectable, there was a switch in the binding specificity of the HSPG to FGF-1. Thus, a single species of HSPG undergoes a rapid, tightly controlled change in growth factor-binding specificity concomitant with the temporal expression of the FGFs.
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