| First Author | Barrôco RM | Year | 2003 |
| Journal | Cell Mol Life Sci | Volume | 60 |
| Issue | 2 | Pages | 401-12 |
| PubMed ID | 12678503 | Mgi Jnum | J:82628 |
| Mgi Id | MGI:2654283 | Doi | 10.1007/s000180300033 |
| Citation | Barroco RM, et al. (2003) Novel complexes of cyclin-dependent kinases and a cyclin-like protein from Arabidopsis thaliana with a function unrelated to cell division. Cell Mol Life Sci 60(2):401-12 |
| abstractText | Although the majority of cyclin-dependent kinases (CDKs) play a key role in cell cycle progression, recent evidence has shown that CDKs are also implicated in transcription regulation. Here, we describe two Arabidopsis CDKs designated Arath;CDKC;1 and Arath; CDKC;2. These CDKs share a PITAIRE signature in the cyclin-binding domain and the structural characteristics of mammalian CDK9. Yeast two-hybrid screens and immunoprecipitation assays identified CDKC-interacting proteins with homology to the animal cyclin T/cyclin K group. We suggest that these Arabidopsis CDKCs may be part of a kinase complex similar to the animal positive transcription elongation factor b, whose activity is essential for transcription control. Expression studies showed that Arath; CDKC transcripts are mainly confined to epidermal tissues and are most abundant in flower tissues. No expression was detected in actively dividing Arabidopsis tissues, suggesting a role for the CDKC proteins in differentiated cells. |
