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Publication : Giant lysosomes in the renal proximal tubules--a morphological characteristic of DBA/2 and DBA/1 mouse kidneys.

First Author  Yabuki A Year  2003
Journal  Exp Anim Volume  52
Issue  2 Pages  159-63
PubMed ID  12806891 Mgi Jnum  J:83766
Mgi Id  MGI:2663537 Doi  10.1538/expanim.52.159
Citation  Yabuki A, et al. (2003) Giant lysosomes in the renal proximal tubules--a morphological characteristic of DBA/2 and DBA/1 mouse kidneys. Exp Anim 52(2):159-63
abstractText  The DBA/2Cr mouse is characterized by the presence of giant lysosomes located in the proximal convoluted tubules of males and proximal straight tubules of females. However, it remains unclear whether these giant lysosomes in the proximal tubules are characteristic of DBA/2Cr specifically, or are common to other DBA/2 substrains and DBA/1. The present study investigated the morphology of kidneys from DBA/2CrSlc, DBA/2JJcl, DBA/2NCrj and DBA/1JNCrj mice of both sexes. Giant lysosomes in the renal proximal tubules were found to represent common morphological characteristic of both DBA/2 and DBA/1JN.
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