| First Author | Wang T | Year | 2003 |
| Journal | J Immunol | Volume | 171 |
| Issue | 5 | Pages | 2524-31 |
| PubMed ID | 12928402 | Mgi Jnum | J:85850 |
| Mgi Id | MGI:2677130 | Doi | 10.4049/jimmunol.171.5.2524 |
| Citation | Wang T, et al. (2003) IFN-gamma-producing gammadelta T cells help control murine West Nile virus infection. J Immunol 171(5):2524-31 |
| abstractText | West Nile (WN) virus causes fatal meningoencephalitis in laboratory mice, thereby partially mimicking human disease. Using this model, we have demonstrated that mice deficient in gammadelta T cells are more susceptible to WN virus infection. TCRdelta(-/-) mice have elevated viral loads and greater dissemination of the pathogen to the CNS. In wild-type mice, gammadelta T cells expanded significantly during WN virus infection, produced IFN-gamma in ex vivo assays, and enhanced perforin expression by splenic T cells. Adoptive transfer of gammadelta T cells to TCRdelta(-/-) mice reduced the susceptibility of these mice to WN virus, and this effect was primarily due to IFN-gamma-producing gammadelta T cells. These data demonstrate a distinct role for gammadelta T cells in the control of and prevention of mortality from murine WN virus infection. |
