| First Author | Debus A | Year | 2003 |
| Journal | Infect Immun | Volume | 71 |
| Issue | 12 | Pages | 7215-8 |
| PubMed ID | 14638820 | Mgi Jnum | J:86648 |
| Mgi Id | MGI:2681027 | Doi | 10.1128/IAI.71.12.7215-7218.2003 |
| Citation | Debus A, et al. (2003) High levels of susceptibility and T helper 2 response in MyD88-deficient mice infected with Leishmania major are interleukin-4 dependent. Infect Immun 71(12):7215-8 |
| abstractText | Myeloid differentiation protein 88 (MyD88) is a general adaptor for the signaling cascade through receptors of the Toll/IL-1R family. When infected with Leishmania major parasites, MyD88-deficient mice displayed a dramatically enhanced parasite burden in their tissues similar to that found in susceptible BALB/c mice. In contrast, MyD88 knockout mice did not develop ulcerating lesions despite a lack of interleukin-12 (IL-12) production and a predominant T helper 2 cell response. Blockade of IL-4 produced early (day 1) after infection restored a protective T helper 1 response in MyD88 knockout mice. |
