| First Author | Vajjhala PR | Year | 2003 |
| Journal | FEBS Lett | Volume | 554 |
| Issue | 1-2 | Pages | 143-8 |
| PubMed ID | 14596929 | Mgi Jnum | J:86380 |
| Mgi Id | MGI:2679750 | Doi | 10.1016/s0014-5793(03)01144-x |
| Citation | Vajjhala PR, et al. (2003) The Wilms' tumour suppressor protein, WT1, undergoes CRM1-independent nucleocytoplasmic shuttling. FEBS Lett 554(1-2):143-8 |
| abstractText | The Wilms' tumour suppressor gene (WT1) encodes a zinc finger-containing nuclear protein essential for kidney and urogenital development. Initially considered a transcription factor, there is mounting evidence that WT1 has a role in post-transcriptional processing. Using the interspecies heterokaryon assay, we have demonstrated that WT1 can undergo nucleocytoplasmic shuttling. We have also mapped the region responsible for nuclear export to residues 182-324. Our data add further complexity to the role of WT1 in transcriptional and post-transcriptional regulation. |
