| First Author | McMorrow I | Year | 1994 |
| Journal | Biochim Biophys Acta | Volume | 1217 |
| Issue | 2 | Pages | 219-23 |
| PubMed ID | 8110839 | Mgi Jnum | J:17101 |
| Mgi Id | MGI:65154 | Doi | 10.1016/0167-4781(94)90040-x |
| Citation | McMorrow I, et al. (1994) Sequence analysis of a cDNA encoding a human nuclear pore complex protein, hnup153. Biochim Biophys Acta 1217(2):219-23 |
| abstractText | Nuclear pore complexes represent the channels for the the bi-directional movement of macromolecules between the nucleus and cytoplasm, and are thought to contain upwards of 100 different polypeptide subunits. Many of these subunits belong to a growing family of polypeptides termed nucleoporins which are characterized by the presence of O-linked N-acetylglucosamine moieties and a distinctive pentapeptide repeat (XFXFG). This paper reports the primary structure of hnup153, the human homologue of the rat nucleoporin, nup153, with which it shares 82% amino acid identity. In addition to 33 copies of the XFXFG repeat, hnup153 exhibits four repeats of 37-38 amino acids each containing an apparent 'zinc finger motif'. These zinc fingers are most closely related to those found in the mouse oncoprotein mdm-2 and a product of Drosphila small optic lobes (sol) gene. |
