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Publication : Induction of lymphoma in CDF1 mice by the food mutagen, 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine.

First Author  Esumi H Year  1989
Journal  Jpn J Cancer Res Volume  80
Issue  12 Pages  1176-8
PubMed ID  2516847 Mgi Jnum  J:90311
Mgi Id  MGI:3042852 Doi  10.1111/j.1349-7006.1989.tb01651.x
Citation  Esumi H, et al. (1989) Induction of lymphoma in CDF1 mice by the food mutagen, 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine. Jpn J Cancer Res 80(12):1176-8
abstractText  The mutagenic compound, 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP), originally isolated from cooked beef, was tested for carcinogenicity in CDF1 mice of both sexes. When PhIP was given in the diet at a concentration of 0.04%, high incidences and early appearances of lymphomas were observed in both sexes during the 579-day experiment.
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