| First Author | Assarsson E | Year | 2004 |
| Journal | J Immunol | Volume | 173 |
| Issue | 1 | Pages | 174-80 |
| PubMed ID | 15210772 | Mgi Jnum | J:90929 |
| Mgi Id | MGI:3045530 | Doi | 10.4049/jimmunol.173.1.174 |
| Citation | Assarsson E, et al. (2004) NK cells stimulate proliferation of T and NK cells through 2B4/CD48 interactions. J Immunol 173(1):174-80 |
| abstractText | Few studies have addressed the consequences of physical interactions between NK and T cells, as well as physical interactions among NK cells themselves. We show in this study that NK cells can enhance T cell activation and proliferation in response to CD3 cross-linking and specific Ag through interactions between 2B4 (CD244) on NK cells and CD48 on T cells. Furthermore, 2B4/CD48 interactions between NK cells also enhanced proliferation of NK cells in response to IL-2. Overall, these results suggest that NK cells augment the proliferation of neighboring T and NK cells through direct cell-cell contact. These results provide new insights into NK cell-mediated control of innate and adaptive immunity and demonstrate that receptor/ligand-specific cross talk between lymphocytes may occur in settings other than T-B cell or T-T cell interactions. |
