| First Author | Bevan D | Year | 2004 |
| Journal | J Pathol | Volume | 203 |
| Issue | 3 | Pages | 831-8 |
| PubMed ID | 15221943 | Mgi Jnum | J:90674 |
| Mgi Id | MGI:3044450 | Doi | 10.1002/path.1578 |
| Citation | Bevan D, et al. (2004) Diverse and potent activities of HGF/SF in skin wound repair. J Pathol 203(3):831-8 |
| abstractText | Genetic studies in the mouse have highlighted essential roles for several growth factors in skin repair and have offered a rationale for their use in therapy. The present study shows that the plasminogen-related growth factor HGF/SF (hepatocyte growth factor/scatter factor) promotes wound repair in homozygous diabetic db/db mice by recruiting neutrophils, monocytes, and mast cells to the wound; by promoting the migration of endothelial cells to the injured area; and by enhancing keratinocyte migration and proliferation. As a result, granulation tissue formation, wound angiogenesis, and re-epithelialization are all increased. The results demonstrate that HGF/SF affects and sustains all key cellular processes responsible for wound repair and point to a unique potential of this molecule for the therapy of chronic skin wounds. |
