| First Author | Kaput J | Year | 2004 |
| Journal | Physiol Genomics | Volume | 18 |
| Issue | 3 | Pages | 316-24 |
| PubMed ID | 15306695 | Mgi Jnum | J:91835 |
| Mgi Id | MGI:3050918 | Doi | 10.1152/physiolgenomics.00065.2003 |
| Citation | Kaput J, et al. (2004) Identification of genes contributing to the obese yellow Avy phenotype: caloric restriction, genotype, diet x genotype interactions. Physiol Genomics 18(3):316-24 |
| abstractText | The incidence and severity of obesity and type 2 diabetes are increasing in Western societies. The progression of obesity to type 2 diabetes is gradual with overlapping symptoms of insulin resistance, hyperinsulinemia, hyperglycemia, dyslipidemias, ion imbalance, and inflammation; this complex syndrome has been called diabesity. We describe here comparisons of gene expression in livers of A/a (agouti) vs. A(vy)/A (obese yellow) segregants (i.e., littermates) from BALB/cStCrlfC3H/Nctr x VYWffC3Hf/Nctr-A(vy)/a matings in response to 70% and 100% of ad libitum caloric intakes of a reproducible diet. Twenty-eight (28) genes regulated by diet, genotype, or diet x genotype interactions mapped to diabesity quantitative trait loci. A subset of the identified genes is linked to abnormal physiological signs observed in obesity and diabetes. |
