| First Author | Nishimura H | Year | 2004 |
| Journal | J Virol | Volume | 78 |
| Issue | 9 | Pages | 4927-30 |
| PubMed ID | 15078977 | Mgi Jnum | J:89247 |
| Mgi Id | MGI:3039222 | Doi | 10.1128/JVI.78.9.4927-4930.2004 |
| Citation | Nishimura H, et al. (2004) Intraepithelial gammadelta T cells may bridge a gap between innate immunity and acquired immunity to herpes simplex virus type 2. J Virol 78(9):4927-30 |
| abstractText | Mice depleted of gammadelta T cells by in vivo administration of anti-TCRgammadelta monoclonal antibodies showed susceptibility against an intravaginal infection with herpes simplex virus type 2 (HSV-2). The systemic Th1 response was impaired in the gammadelta T-cell-depleted mice. Mice deficient in the Vdelta1 T subset were susceptible to an intravaginal infection with HSV-2. Intraepithelial gammadelta T cells bearing Vdelta1 may help protect against intravaginal infection with HSV-2 through promoting the systemic Th1 response. |
