| First Author | Gorska MM | Year | 2004 |
| Journal | J Exp Med | Volume | 199 |
| Issue | 3 | Pages | 369-79 |
| PubMed ID | 14757743 | Mgi Jnum | J:90462 |
| Mgi Id | MGI:3043901 | Doi | 10.1084/jem.20030589 |
| Citation | Gorska MM, et al. (2004) Unc119, a novel activator of Lck/Fyn, is essential for T cell activation. J Exp Med 199(3):369-79 |
| abstractText | The first step in T cell receptor for antigen (TCR) signaling is the activation of the receptor-bound Src kinases, Lck and Fyn. The exact mechanism of this process is unknown. Here, we report that the novel Src homology (SH) 3/SH2 ligand-Uncoordinated 119 (Unc119) associates with CD3 and CD4, and activates Lck and Fyn. Unc119 overexpression increases Lck/Fyn activity in T cells. In Unc119-deficient T cells, Lck/Fyn activity is dramatically reduced with concomitant decrease in interleukin 2 production and cellular proliferation. Reconstitution of cells with Unc119 reverses the signaling and functional outcome. Thus, Unc119 is a receptor-associated activator of Src-type kinases. It provides a novel mechanism of signal generation in the TCR complex. |
