| First Author | Zheng G | Year | 2004 |
| Journal | J Immunol | Volume | 173 |
| Issue | 4 | Pages | 2428-34 |
| PubMed ID | 15294956 | Mgi Jnum | J:92682 |
| Mgi Id | MGI:3054296 | Doi | 10.4049/jimmunol.173.4.2428 |
| Citation | Zheng G, et al. (2004) The 4-1BB costimulation augments the proliferation of CD4+CD25+ regulatory T cells. J Immunol 173(4):2428-34 |
| abstractText | The thymus-derived CD4(+)CD25(+) T cells belong to a subset of regulatory T cells potentially capable of suppressing the proliferation of pathogenic effector T cells. Intriguingly, these suppressor cells are themselves anergic, proliferating poorly to mitogenic stimulation in culture. In this study, we find that the 4-1BB costimulator receptor, best known for promoting the proliferation and survival of CD8(+) T cells, also induces the proliferation of the CD4(+)CD25(+) regulatory T cells both in culture and in vivo. The proliferating CD4(+)CD25(+) T cells produce no detectable IL-2, suggesting that 4-1BB costimulation of these cells does not involve IL-2 production. The 4-1BB-expanded CD4(+)CD25(+) T cells are functional, as they remain suppressive to other T cells in coculture. These results support the notion that the peripheral expansion of the CD4(+)CD25(+) T cells is controlled in part by costimulation. |
