| First Author | Liao G | Year | 2004 |
| Journal | Science | Volume | 306 |
| Issue | 5696 | Pages | 690-5 |
| PubMed ID | 15499019 | Mgi Jnum | J:93222 |
| Mgi Id | MGI:3056249 | Doi | 10.1126/science.1100636 |
| Citation | Liao G, et al. (2004) In silico genetics: identification of a functional element regulating H2-Ealpha gene expression. Science 306(5696):690-5 |
| abstractText | Computational tools can markedly accelerate the rate at which murine genetic models can be analyzed. We developed a computational method for mapping phenotypic traits that vary among inbred strains onto haplotypic blocks. This method correctly predicted the genetic basis for strain-specific differences in several biologically important traits. It was also used to identify an allele-specific functional genomic element regulating H2-Ealpha gene expression. This functional element, which contained the binding sites for YY1 and a second transcription factor that is probably serum response factor, is located within the first intron of the H2-Ealpha gene. This computational method will greatly improve our ability to identify the genetic basis for a variety of phenotypic traits, ranging from qualitative trait information to quantitative gene expression data, which vary among inbred mouse strains. |
