| First Author | St-Pierre B | Year | 2004 |
| Journal | Gene Expr Patterns | Volume | 5 |
| Issue | 2 | Pages | 245-51 |
| PubMed ID | 15567721 | Mgi Jnum | J:94055 |
| Mgi Id | MGI:3510580 | Doi | 10.1016/j.modgep.2004.07.009 |
| Citation | St-Pierre B, et al. (2004) High expression during neurogenesis but not mammogenesis of a murine homologue of the Deleted in Breast Cancer2/Rhobtb2 tumor suppressor. Gene Expr Patterns 5(2):245-251 |
| abstractText | Deleted in Breast Cancer-2, Dbc2, identified as a candidate tumor suppressor gene for breast cancer and other human malignancies, is a member of a novel gene family encoding putative small GTPases designated as Rhobtb. In this report, we describe the spatio-temporal expression of mDbc2/Rhobtb2 mRNA during mammary gland development and embryogenesis in the mouse. We have first determined that mDbc2/Rhobtb2 transcripts are expressed at low, but seemingly constant levels during mammopoiesis. Secondly, we have found that mDbc2/Rhobtb2 is expressed highly and specifically in the central and peripheral nervous systems during mouse embryogenesis. While our results do not reveal any connection between elevated expression of mDbc2/Rhobtb2 and a specific stage of mammary gland development, they strongly support a role for this gene during development of the nervous system. |
