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Publication : Ephrin-A5 overexpression degrades topographic specificity in the mouse gluteus maximus muscle.

First Author  Lampa SJ Year  2004
Journal  Brain Res Dev Brain Res Volume  153
Issue  2 Pages  271-4
PubMed ID  15527895 Mgi Jnum  J:94638
Mgi Id  MGI:3513632 Doi  10.1016/j.devbrainres.2004.09.005
Citation  Lampa SJ, et al. (2004) Ephrin-A5 overexpression degrades topographic specificity in the mouse gluteus maximus muscle. Brain Res Dev Brain Res 153(2):271-4
abstractText  Motor neurons project onto specific muscles with a distinct positional bias. We have previously shown using electrophysiological techniques that overexpression of ephrin-A5 degrades this topographic map. Here, we show that positional differences in axon terminal areas, an entirely different parameter of neuromuscular topography, are also eliminated with ephrin-A5 overexpression. Therefore, we now have both morphological and electrophysiological approaches to explore the mechanisms of neuromuscular topography.
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