| First Author | Kremyanskaya M | Year | 2005 |
| Journal | J Immunol | Volume | 174 |
| Issue | 3 | Pages | 1501-6 |
| PubMed ID | 15661909 | Mgi Jnum | J:96409 |
| Mgi Id | MGI:3530406 | Doi | 10.4049/jimmunol.174.3.1501 |
| Citation | Kremyanskaya M, et al. (2005) Ig-independent Ig beta expression on the surface of B lymphocytes after B cell receptor aggregation. J Immunol 174(3):1501-6 |
| abstractText | In order for humoral immune responses to develop, B cells must be able to recognize, bind, and internalize Ags. These functions are performed by the BCR, which is also responsible for initiating and transducing activation signals necessary for B cell proliferation and differentiation. We have examined surface expression patterns of individual components of the BCR following anti-Ig- and Ag-induced aggregation. Specifically, the localization and expression levels of the Ag-binding component, surface Ig (sIg), and the Igbeta component of the Igalpha/Igbeta signaling unit were investigated to determine their individual participation in the internalization and signal transduction. Using primary murine B cells, we found that while >95% of the sIg is internalized following anti-Ig-induced aggregation, 20-30% of Igbeta remains on the surface. These results suggest that sIg and Igbeta may function independently following the initial stages of signal transduction. |
