| First Author | Hwang HC | Year | 2005 |
| Journal | Oncogene | Volume | 24 |
| Issue | 17 | Pages | 2776-86 |
| PubMed ID | 15838514 | Mgi Jnum | J:97941 |
| Mgi Id | MGI:3576802 | Doi | 10.1038/sj.onc.1208613 |
| Citation | Hwang HC, et al. (2005) Cyclin E in normal and neoplastic cell cycles. Oncogene 24(17):2776-86 |
| abstractText | Cyclin E-Cdk2 has long been considered an essential and master regulator of progression through G1 phase of the cell cycle. Although recent mouse models have prompted a rethinking of cyclin E function in mammals, it remains clear that cyclin E impacts upon many processes central to cell division. Normal cells maintain strict control of cyclin E activity, and this is commonly disrupted in cancer cells. Moreover, cyclin E deregulation is thought to play a fundamental role in tumorigenesis. In this review, we discuss the regulation and functions of cyclin E in normal and neoplastic mammalian cells. |
