| First Author | Whitmire JK | Year | 2005 |
| Journal | J Exp Med | Volume | 201 |
| Issue | 7 | Pages | 1053-9 |
| PubMed ID | 15809350 | Mgi Jnum | J:98001 |
| Mgi Id | MGI:3576945 | Doi | 10.1084/jem.20041463 |
| Citation | Whitmire JK, et al. (2005) Interferon-gamma acts directly on CD8+ T cells to increase their abundance during virus infection. J Exp Med 201(7):1053-9 |
| abstractText | Interferon-gamma (IFNgamma) is important in regulating the adaptive immune response, and most current evidence suggests that it exerts a negative (proapoptotic) effect on CD8(+) T cell responses. We have developed a novel technique of dual adoptive transfer, which allowed us to precisely compare, in normal mice, the in vivo antiviral responses of two T cell populations that differ only in their expression of the IFNgamma receptor. We use this technique to show that, contrary to expectations, IFNgamma strongly stimulates the development of CD8(+) T cell responses during an acute viral infection. The stimulatory effect is abrogated in T cells lacking the IFNgamma receptor, indicating that the cytokine acts directly upon CD8(+) T cells to increase their abundance during acute viral infection. |
