| First Author | Frade JM | Year | 2005 |
| Journal | J Neurosci | Volume | 25 |
| Issue | 6 | Pages | 1407-11 |
| PubMed ID | 15703394 | Mgi Jnum | J:98101 |
| Mgi Id | MGI:3577146 | Doi | 10.1523/JNEUROSCI.3798-04.2005 |
| Citation | Frade JM (2005) Nuclear translocation of the p75 neurotrophin receptor cytoplasmic domain in response to neurotrophin binding. J Neurosci 25(6):1407-11 |
| abstractText | The intracellular domain of the p75 neurotrophin receptor (p75ICD) can be released by gamma-secretase in response to the previous activation of alpha-secretase by phorbol esters. However, ligand-dependent release of p75ICD has yet to be described. We show here that nerve growth factor can induce the release of p75ICD and facilitate its translocation to the nucleus in a gamma-secretase-dependent manner. This effect was observed in RN22 schwannoma cells cultured under serum-free conditions, as well as in Schwann cells, and it was mimicked by other neurotrophins, such as brain-derived neurotrophic factor or neurotrophin-3. Unlike other known examples of regulated intramembrane proteolysis, ligand-dependent release of p75ICD did not need the previous activation of alpha-secretase. These results suggest that nuclear translocation of p75ICD may represent a novel neurotrophin-mediated signaling pathway. |
