| First Author | Shou S | Year | 2005 |
| Journal | Dev Dyn | Volume | 234 |
| Issue | 1 | Pages | 74-89 |
| PubMed ID | 16059910 | Mgi Jnum | J:100233 |
| Mgi Id | MGI:3587513 | Doi | 10.1002/dvdy.20514 |
| Citation | Shou S, et al. (2005) Transcriptome analysis of the murine forelimb and hindlimb autopod. Dev Dyn 234(1):74-89 |
| abstractText | To gain insight into the coordination of gene expression profiles during forelimb and hindlimb differentiation, a transcriptome analysis of mouse embryonic autopod tissues was performed using Affymetrix Murine Gene Chips (MOE-430). Forty-four transcripts with expression differences higher than 2-fold (T test, P < or = 0.05) were detected between forelimb and hindlimb tissues including 38 new transcripts such as Rdh10, Frzb, Tbx18, and Hip that exhibit differential limb expression. A comparison of gene expression profiles in the forelimb, hindlimb, and brain revealed 24 limb-signature genes whose expression was significantly enriched in limb autopod versus brain tissue (fold change >2, P < or = 0.05). Interestingly, the genes exhibiting enrichment in the developing autopod also segregated into significant fore- and hindlimb-specific clusters (P < or = 0.05) suggesting that by E 12.5, unique gene combinations are being used during the differentiation of each autopod type. |
