| First Author | Kiapekou E | Year | 2005 |
| Journal | Reprod Biomed Online | Volume | 10 |
| Issue | 3 | Pages | 339-46 |
| PubMed ID | 15820039 | Mgi Jnum | J:100447 |
| Mgi Id | MGI:3588553 | Doi | 10.1016/s1472-6483(10)61793-2 |
| Citation | Kiapekou E, et al. (2005) Prolactin receptor mRNA expression in oocytes and preimplantation mouse embryos. Reprod Biomed Online 10(3):339-46 |
| abstractText | Prolactin was first identified as an anterior pituitary lobe hormone, responsible for the regulation of mammary gland growth and development. Prolactin receptors have been localized in a number of peripheral tissues, including tissues involved in reproduction. Studies with knockout animals have shown that prolactin receptor deficient mice present reproductive defects, whereas prolactin promotes the developmental potential of preimplantation mouse and rat embryos in vitro. To better understand the role of prolactin in the process of reproduction and early embryo development in mice, the expression of the four transcript variants of prolactin receptor was examined in the first stages of mouse embryo development. Prolactin long receptor mRNA was expressed in all stages examined, that is in cumulus cells, oocytes, zygotes, 2-cell embryos, 4-cell embryos, morulae and blastocysts. Prolactin receptor type S1 mRNA was observed only in cumulus cells, while S2 mRNA was present in cumulus cells, oocytes, zygotes and 2-cell embryos. S3 mRNA was expressed only in cumulus cells and oocytes. These results indicate that different isoforms of prolactin receptors may be present in the various stages of mouse preimplantation embryo and may play an important role in the control of its growth and development. |
