| First Author | Piqueras L | Year | 2004 |
| Journal | Peptides | Volume | 25 |
| Issue | 8 | Pages | 1287-95 |
| PubMed ID | 15350696 | Mgi Jnum | J:102429 |
| Mgi Id | MGI:3607490 | Doi | 10.1016/j.peptides.2004.06.003 |
| Citation | Piqueras L, et al. (2004) Galanin inhibits gastric acid secretion through a somatostatin-independent mechanism in mice. Peptides 25(8):1287-95 |
| abstractText | The role of somatostatin in galanin-induced inhibition of gastric acid secretion in urethane-anesthetized mice was investigated by using immunoneutralization of endogenous somatostatin and somatostatin receptor type 2 (SSTR2) knockout mice. Intravenous galanin (10 and 20 microg/kg/h) inhibited pentagastrin-stimulated gastric acid secretion by 47 and 33%, respectively. Somatostatin antibody injected i.v. increased acid secretion by 3.5-fold over basal levels but did not modify the antisecretory effects of galanin. Urethane-anesthetized SSTR2 knockout mice had a basal secretion 14-fold higher than wild-type animals, that was inhibited by galanin (10 and 20 microg/kg/h) by 49 and 31% respectively. In mice galanin inhibits gastric acid secretion through a somatostatin-independent mechanism. |
