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Publication : Expression of Fgf and Tgfbeta signaling related genes during embryonic endochondral ossification.

First Author  Minina E Year  2005
Journal  Gene Expr Patterns Volume  6
Issue  1 Pages  102-9
PubMed ID  15963767 Mgi Jnum  J:103164
Mgi Id  MGI:3608575 Doi  10.1016/j.modgep.2005.04.012
Citation  Minina E, et al. (2005) Expression of Fgf and Tgfbeta signaling related genes during embryonic endochondral ossification. Gene Expr Patterns 6(1):102-109
abstractText  Disturbed fibroblast growth factor (Fgf) and transforming growth factor beta (Tgfbeta) signaling lead to a variety of human skeletal disorders. To reveal the possible function and interaction of these signaling systems we have started to analyze the expression patterns of signaling factors, antagonists, receptors and transducers of these pathways in forelimbs of mouse embryos and compared them to the expression of established markers including Ihh. In addition to defining their expression domains in the developing bone, our study identified new subpopulations of chondrocytes characterized by the expression of distinct combinations of markers.
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