| First Author | Bonaguidi MA | Year | 2005 |
| Journal | Development | Volume | 132 |
| Issue | 24 | Pages | 5503-14 |
| PubMed ID | 16314487 | Mgi Jnum | J:104352 |
| Mgi Id | MGI:3611701 | Doi | 10.1242/dev.02166 |
| Citation | Bonaguidi MA, et al. (2005) LIF and BMP signaling generate separate and discrete types of GFAP-expressing cells. Development 132(24):5503-14 |
| abstractText | Bone morphogenetic protein (BMP) and leukemia inhibitory factor (LIF) signaling both promote the differentiation of neural stem/progenitor cells into glial fibrillary acidic protein (GFAP) immunoreactive cells. This study compares the cellular and molecular characteristics, and the potentiality, of GFAP(+) cells generated by these different signaling pathways. Treatment of cultured embryonic subventricular zone (SVZ) progenitor cells with LIF generates GFAP(+) cells that have a bipolar/tripolar morphology, remain in cell cycle, contain progenitor cell markers and demonstrate self-renewal with enhanced neurogenesis - characteristics that are typical of adult SVZ and subgranular zone (SGZ) stem cells/astrocytes. By contrast, BMP-induced GFAP(+) cells are stellate, exit the cell cycle, and lack progenitor traits and self-renewal |
