| First Author | Amrein L | Year | 2005 |
| Journal | Cell Tissue Res | Volume | 322 |
| Issue | 3 | Pages | 365-78 |
| PubMed ID | 16082520 | Mgi Jnum | J:105464 |
| Mgi Id | MGI:3615103 | Doi | 10.1007/s00441-005-0036-9 |
| Citation | Amrein L, et al. (2005) Expression patterns of nm23 genes during mouse organogenesis. Cell Tissue Res 322(3):365-78 |
| abstractText | Nucleoside di-phosphate kinase enzyme (NDPK) isoforms, encoded by the nm23 family of genes, may be involved in various cellular differentiation and proliferation processes. We have therefore analyzed the expression of nm23-M1, -M2, -M3, and -M4 during embryonic mouse development. In situ hybridization data has revealed the differential expression of nm23 mRNA during organogenesis. Whereas nm23-M1 and -M3 are preferentially expressed in the nervous and sensory systems, nm23-M2 mRNA is found ubiquitously. Irrespective of the developmental state studied, nm23-M4 mRNA is only expressed at low levels in a few embryonic organs. In the cerebellum and cerebral cortex, nm23-M1, -M2, and -M3 are present in the neuronal differentiation layer, whereas nm23-M4 mRNA is distributed in the proliferating layer. Thus, nm23 mRNA is differentially expressed, and the diverse NDPK isoforms are sequentially involved in various developmental processes. |
