| First Author | Schulz R | Year | 2006 |
| Journal | Mamm Genome | Volume | 17 |
| Issue | 3 | Pages | 239-47 |
| PubMed ID | 16518691 | Mgi Jnum | J:106438 |
| Mgi Id | MGI:3618558 | Doi | 10.1007/s00335-005-0126-8 |
| Citation | Schulz R, et al. (2006) Nondisjunction and transmission ratio distortion of Chromosome 2 in a (2.8) Robertsonian translocation mouse strain. Mamm Genome 17(3):239-47 |
| abstractText | Aneuploidy results from nondisjunction of chromosomes in meiosis and is the leading cause of developmental disabilities and mental retardation in humans. Therefore, understanding aspects of chromosome segregation in a genetic model is of value. Mice heterozygous for a (2.8) Robertsonian translocation were intercrossed with chromosomally normal mice and Chromosome 2 was genotyped for number and parental origin in 836 individuals at 8.5 dpc. The frequency of nondisjunction of this Robertsonian chromosome is 1.58%. Trisomy of Chromosome 2 with two maternally derived chromosomes is the most developmentally successful aneuploid karyotype at 8.5 dpc. Trisomy of Chromosome 2 with two paternally derived chromosomes is developmentally delayed and less frequent than the converse. Individuals with maternal or paternal uniparental disomy of Chromosome 2 were not detected at 8.5 dpc. Nondisjunction events were distributed randomly across litters, i.e., no evidence for clustering was found. Transmission ratio distortion is frequently observed in Robertsonian chromosomes and a bias against the transmission of the (2.8) Chromosome was detected. Interestingly, this was observed for female and male transmitting parents. |
