| First Author | Farley N | Year | 2006 |
| Journal | Mol Cell Biol | Volume | 26 |
| Issue | 6 | Pages | 2118-29 |
| PubMed ID | 16507991 | Mgi Jnum | J:106915 |
| Mgi Id | MGI:3619769 | Doi | 10.1128/MCB.26.6.2118-2129.2006 |
| Citation | Farley N, et al. (2006) p38 mitogen-activated protein kinase mediates the Fas-induced mitochondrial death pathway in CD8+ T cells. Mol Cell Biol 26(6):2118-29 |
| abstractText | The p38 mitogen-activated protein kinase (MAPK) signaling pathway can be activated by a variety of stress stimuli such as UV radiation and osmotic stress. The regulation and role of this pathway in death receptor-induced apoptosis remain unclear and may depend on the specific death receptor and cell type. Here we show that binding of Fas ligand to Fas activates p38 MAPK in CD8+ T cells and that activation of this pathway is required for Fas-mediated CD8+ T-cell death. Active p38 MAPK phosphorylates Bcl-xL and Bcl-2 and prevents the accumulation of these antiapoptotic molecules within the mitochondria. Consequently, a loss of mitochondrial membrane potential and the release of cytochrome c lead to the activation of caspase 9 and, subsequently, caspase 3. Therefore, the activation of p38 MAPK is a critical link between Fas and the mitochondrial death pathway and is required for the Fas-induced apoptosis of CD8+ T cells. |
