| First Author | Ostman A | Year | 2006 |
| Journal | Nat Rev Cancer | Volume | 6 |
| Issue | 4 | Pages | 307-20 |
| PubMed ID | 16557282 | Mgi Jnum | J:107427 |
| Mgi Id | MGI:3621115 | Doi | 10.1038/nrc1837 |
| Citation | Ostman A, et al. (2006) Protein-tyrosine phosphatases and cancer. Nat Rev Cancer 6(4):307-20 |
| abstractText | Tyrosine phosphorylation is an important signalling mechanism in eukaryotic cells. In cancer, oncogenic activation of tyrosine kinases is a common feature, and novel anticancer drugs have been introduced that target these enzymes. Tyrosine phosphorylation is also controlled by protein-tyrosine phosphatases (PTPs). Recent evidence has shown that PTPs can function as tumour suppressors. In addition, some PTPs, including SHP2, positively regulate the signalling of growth-factor receptors, and can be oncogenic. An improved understanding of how these enzymes function and how they are regulated might aid the development of new anticancer agents. |
