| First Author | Grohmann U | Year | 2002 |
| Journal | Nat Immunol | Volume | 3 |
| Issue | 11 | Pages | 1097-101 |
| PubMed ID | 12368911 | Mgi Jnum | J:109254 |
| Mgi Id | MGI:3626167 | Doi | 10.1038/ni846 |
| Citation | Grohmann U, et al. (2002) CTLA-4-Ig regulates tryptophan catabolism in vivo. Nat Immunol 3(11):1097-101 |
| abstractText | Cytotoxic T lymphocyte-associated antigen 4 (CTLA-4) plays a critical role in peripheral tolerance. However, regulatory pathways initiated by the interactions of CTLA-4 with B7 counterligands expressed on antigen-presenting cells are not completely understood. We show here that long-term survival of pancreatic islet allografts induced by the soluble fusion protein CTLA-4-immunoglobulin (CTLA-4-Ig) is contingent upon effective tryptophan catabolism in the host. In vitro, we show that CTLA-4-Ig regulates cytokine-dependent tryptophan catabolism in B7-expressing dendritic cells. These data suggest that modulation of tryptophan catabolism is a means by which CTLA-4 functions in vivo and that CTLA-4 acts as a ligand for B7 receptor molecules that transduce intracellular signals. |
