| First Author | Myung PS | Year | 2001 |
| Journal | Immunity | Volume | 15 |
| Issue | 6 | Pages | 1011-26 |
| PubMed ID | 11754821 | Mgi Jnum | J:110507 |
| Mgi Id | MGI:3640429 | Doi | 10.1016/s1074-7613(01)00253-9 |
| Citation | Myung PS, et al. (2001) Differential requirement for SLP-76 domains in T cell development and function. Immunity 15(6):1011-26 |
| abstractText | The hematopoietic cell-specific adaptor protein, SLP-76, is critical for T cell development and mature T cell receptor (TCR) signaling; however, the structural requirements of SLP-76 for mediating thymopoiesis and mature T cell function remain largely unknown. In this study, transgenic mice were generated to examine the requirements for specific domains of SLP-76 in thymocytes and peripheral T cells in vivo. Examination of mice expressing various mutants of SLP-76 on the null background demonstrates a differential requirement for specific domains of SLP-76 in thymocytes and T cells and provides new insight into the molecular mechanisms underlying SLP-76 function. |
