| First Author | Sugawara T | Year | 1998 |
| Journal | Immunity | Volume | 9 |
| Issue | 4 | Pages | 565-74 |
| PubMed ID | 9806642 | Mgi Jnum | J:110525 |
| Mgi Id | MGI:3640447 | Doi | 10.1016/s1074-7613(00)80639-1 |
| Citation | Sugawara T, et al. (1998) Differential roles of ERK and p38 MAP kinase pathways in positive and negative selection of T lymphocytes. Immunity 9(4):565-74 |
| abstractText | Clonal selection of T lymphocytes is essential for establishing self/non-self discrimination of immune recognition. It is known that cell surface signals such as avidity and valency of TCR-ligand interactions influence the fate of individual thymocytes, founding a primary repertoire of T cells. However, intracellular signals that govern positive and negative selection in the thymus have been unclear. The present study using the retroviral gene transfer technique shows that MKK1 activation in developing T cells is sufficient for providing positive selection signals. We also show that the MKK6-p38 signaling pathway is critically involved in inducing negative selection of thymocytes. These results suggest that intracellular signals through different MAP kinase cascades selectively guide positive and negative selection of T lymphocytes. |
